For the convenience of the people of the eponymous district, according to a plaque that was once at the entrance, the Church of Sant’Amico, dedicated to Saints Simon and Jude, was built in April 1587. In the 15th, 16th, and 17th centuries, the district was recorded in land registers and various documents as San Manìco or San Menìco; only during the 18th century did the current name appear. The church is believed to have been constructed on the site of a pre-existing church dedicated to Saint Dominic, from which the popular distortion San Ménico derives.

This small rural church forms a single architectural complex with an adjoining house on its left side. The complex was restored at the end of the 1980s; the Cultural Heritage Authority approved the work provided that the original character of the building was maintained, recognizing it as a “historic monumental building.”

The Church of Saints Simon and Jude of Sant’Amico is home to the Confraternity of the Buon Gesù. Its exact founding date is unknown, but record-keeping began in 1588, one year after the construction of the church. On May 1, 1608, it was affiliated with the Archconfraternity of the Buon Gesù of the Church of Santa Maria sopra Minerva in Rome.

The confraternity remained active in the area until the 1960s. After a long period of inactivity, it was revived in 1978, though it remained largely dormant until recent years. In 2005, with renewed vitality brought by the involvement of some young members, the “Ceremony of Vestition” for new confraternity members was held.