Villa Sant'Amico is a historic 19th-century residence listed with the ADSI (Italian Association of Historic Houses).
The Villa forms the central core, and together with the Orangerie (the former Lemon House), the Little Church, and the Ancient Stables, it makes up the Sant'Amico Estate complex.

The Estate, set within a private 12-hectare park with centuries-old trees, is located in the territory of the ancient Maurum, today known as Morro d'Alba, a medieval village in the province of Ancona, just 10 km from the Adriatic Sea. Vineyards, olive groves, and sea views provide the backdrop for this majestic country residence, which gave its name to the hamlet, previously called San Domenico.

The oldest part of the Villa dates back to 1720 when it was built by the noble Roberti family as a hunting lodge; some frescoes from that era still remain. It was later expanded and enhanced by Count Francesco Carotti in the second half of the 19th century. After completing his studies in Engineering in Leipzig, Germany, he also built the rest of the estate complex. His daughter married a descendant of the poet Giacomo Leopardi of Recanati, and the estate became their summer residence for many years.

At the time of the expansion, technologically advanced innovations were introduced, such as a hot-air heating system with large cast-iron boilers that, through terracotta pipes, heated all 50 rooms of the villa. Liberty-style influences can also be seen in the terracotta exterior decorations on the façades. Meanwhile, the main façade of the Ancient Stables features a fine example of a sundial.